I noticed that when in fullscreen mode in browser like google chrome and firefox, the swf didn´t respond to mouse interaction. I expected to find numerous of post on this weird behaviour but I really didn´t find that much at first glance. I found a post that said that in AS2 the eventListener should have the type set to mouseup to function correctly. I changed the listener type in AS 3 to MouseEvent.MOUSE_UP and voila I had interaction in fullscreen in chrome and firefox. I seldom use IExplorer but with that browser the listener type of down was fine. mmmm standards. May be helpful.